Recent advances in prevention of sepsis in the premature neonates in NICU

Early Hum Dev. 2011 Mar:87 Suppl 1:S31-3. doi: 10.1016/j.earlhumdev.2011.01.008. Epub 2011 Jan 19.


Sepsis-related morbidity and mortality are major problems in NICU. Preterm neonates display clinical characteristics that make them prone to infections. Due to the high frequency of severe neurodevelopmental sequelae in survivors, the best possible strategy to manage sepsis in NICU is to prevent them. Hygiene, cohorting, stewardship on use of H2-blockers, steroids and broad-spectrum antibiotic are mandatory, as well as proper management of central venous accesses and surgical devices. In addition, clinical research offers the opportunity of adopting pharmacological preventative strategies such as use of palivizumab to prevent RSV infection, use of fluconazole to prevent fungal sepsis, use of probiotics and lactoferrin to enhance the innate immunity, and use of pagibaximab to prevent staphylococcal sepsis.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / therapeutic use
  • Antibiotic Prophylaxis / methods
  • Antibiotic Prophylaxis / trends
  • Cost of Illness
  • Drug Delivery Systems / methods
  • Humans
  • Infant, Newborn
  • Infant, Premature* / physiology
  • Infant, Premature, Diseases / prevention & control*
  • Intensive Care Units, Neonatal / trends*
  • Intensive Care, Neonatal / methods
  • Intensive Care, Neonatal / trends*
  • Sepsis / congenital
  • Sepsis / pathology
  • Sepsis / prevention & control*


  • Anti-Infective Agents