Detection of an Ambler Class D OXA-48-type β-lactamase in a Klebsiella Pneumoniae Strain in The Netherlands

J Med Microbiol. 2011 May;60(Pt 5):677-678. doi: 10.1099/jmm.0.028308-0. Epub 2011 Jan 20.


Traditionally, bacteria in The Netherlands have low levels of resistance to antibiotics. This report describes what is believed to be the first carbapenem-resistant Klebsiella pneumoniae producing an OXA-48 type β-lactamase in The Netherlands. The isolate co-produced a CTX-M-15 type β-lactamase and was recovered from a patient who was transferred from a hospital in India to an intensive care unit in The Netherlands. His recovery in The Netherlands was complicated by pneumonia due to the carbapenem-resistant K. pneumoniae to which he eventually succumbed. Pre-emptive screening for carbapenem-resistant Enterobacteriaceae in selected patients could be imperative to maintain the low prevalence of these highly resistant bacteria in Dutch hospitals.

Publication types

  • Case Reports

MeSH terms

  • Carbapenems / pharmacology
  • Fatal Outcome
  • Humans
  • India / ethnology
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / isolation & purification
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Netherlands
  • Pneumonia, Bacterial / drug therapy
  • Pneumonia, Bacterial / microbiology*
  • Travel
  • beta-Lactam Resistance
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / classification*


  • Carbapenems
  • beta-lactamase CTX-M-15
  • beta-Lactamases