[Gender differences in action Fenotropil and its structural analog--compound RGPU-95 on anxiety-depressive behavior animals]

Eksp Klin Farmakol. 2010 Nov;73(11):10-4.
[Article in Russian]


Fenotropil and its structural analog--compound RGPU-95 to a greater extent reduce the severity of anxious and depressive behavior in male rats than in females. On expression of the anxiolytic compound RGPU-95 significantly exceeds Fenotropil, but inferior to Diazepam; of antidepressant activity--comparable to Melipramin and exceeds Fenotropil.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Anxiety / drug therapy
  • Anxiety / physiopathology*
  • Behavior, Animal / drug effects*
  • Depression / drug therapy
  • Depression / physiopathology*
  • Female
  • GABA Modulators / pharmacology*
  • Male
  • Rats
  • Rats, Wistar
  • Sex Characteristics*


  • GABA Modulators