Kinetic study of the antibody response during the blood meal of Ixodes ricinus: implication on plasma cell maturation in vivo and for anti-Ixodes vaccination

Vaccine. 2011 Mar 3;29(11):2044-50. doi: 10.1016/j.vaccine.2011.01.010. Epub 2011 Jan 19.


Anti-tick vaccination could be an ideal solution to prevent pathogen transmission, but none is currently available against Ixodes ticks. Recently, we showed that adult Ixodes ricinus infestation on mice decreases the specific antibody production to BSA injected during infestation. Here, a kinetic study of seric levels of BSA-specific antibodies was performed to evaluate the B memory cell differentiation in Balb/c mice and the capacity of specific B memory cells to respond to BSA during infestation. We concluded that the tick blood meal inhibits or impairs the local differentiation of mature B cells into plasma cells, but does not alter the formation of memory B cell. Accordingly, this mechanism should not be an impediment to anti-Ixodes vaccination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / blood
  • Antibody Formation*
  • B-Lymphocytes / immunology*
  • Cell Differentiation
  • Eating
  • Female
  • Hematopoiesis, Extramedullary
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Immunologic Memory
  • Ixodes / physiology
  • Lymphocyte Activation
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Plasma Cells / immunology*
  • Tick Infestations / immunology*


  • Antibodies
  • Immunoglobulin G
  • Immunoglobulin M