Activity modulation of the bacterial Rho GAP YopE: an inspiration for the investigation of mammalian Rho GAPs

Eur J Cell Biol. 2011 Nov;90(11):951-4. doi: 10.1016/j.ejcb.2010.12.004. Epub 2011 Jan 20.

Abstract

The Yersinia enterocolitica Rho GTPase Activating Protein (Rho GAP) YopE belongs to a group of bacterial virulence factors that is translocated into infected target cells by a type three secretion system. Structurally and biochemically YopE resembles eukaryotic Rho GAPs which control various cellular functions by modulating the activity of Rho GTP binding proteins. Here we summarise the published information on cellular effects, Rho protein substrates, compartmentalisation and turnover of YopE. A fascinating picture evolves of how this virulence factor integrates in host cellular regulatory mechanisms to fine tune bacterial pathogenicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Outer Membrane Proteins / chemistry
  • Bacterial Outer Membrane Proteins / metabolism*
  • Bacterial Toxins / metabolism
  • GTPase-Activating Proteins / chemistry
  • GTPase-Activating Proteins / metabolism*
  • Humans
  • Ubiquitination
  • Yersinia enterocolitica / metabolism*
  • rho GTP-Binding Proteins / metabolism*

Substances

  • Bacterial Outer Membrane Proteins
  • Bacterial Toxins
  • GTPase-Activating Proteins
  • rho GTPase-activating protein
  • yopE protein, Yersinia
  • rho GTP-Binding Proteins