Mitochondrial dysfunction in diabetic cardiomyopathy

Biochim Biophys Acta. 2011 Jul;1813(7):1351-9. doi: 10.1016/j.bbamcr.2011.01.014. Epub 2011 Jan 20.


Cardiovascular disease is common in patients with diabetes and is a significant contributor to the high mortality rates associated with diabetes. Heart failure is common in diabetic patients, even in the absence of coronary artery disease or hypertension, an entity known as diabetic cardiomyopathy. Evidence indicates that myocardial metabolism is altered in diabetes, which likely contributes to contractile dysfunction and ventricular failure. The mitochondria are the center of metabolism, and recent data suggests that mitochondrial dysfunction may play a critical role in the pathogenesis of diabetic cardiomyopathy. This review summarizes many of the potential mechanisms that lead to mitochondrial dysfunction in the diabetic heart. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / metabolism*
  • Diabetic Cardiomyopathies / metabolism*
  • Energy Metabolism*
  • Fatty Acids / blood
  • Heart / physiopathology
  • Heart Failure / metabolism*
  • Humans
  • Mitochondria, Heart / metabolism*
  • Myocardium / metabolism*
  • Oxidative Stress
  • Triglycerides / blood


  • Fatty Acids
  • Triglycerides