Functional motor-cortex mapping using corticokinematic coherence

Neuroimage. 2011 Apr 15;55(4):1475-9. doi: 10.1016/j.neuroimage.2011.01.031. Epub 2011 Jan 19.


We present a novel method, corticokinematic coherence (CKC), for functional mapping of the motor cortex by computing coherence between cortical magnetoencephalographic (MEG) signals and the kinematics of voluntary movements. Ten subjects performed self-paced flexion-extensions of the right-hand fingers at about 3 Hz, with a three-axis accelerometer attached to the index finger. Cross-correlogram and coherence spectra were computed between 306 MEG channels and the accelerometer signals. In all subjects, accelerometer and coherence spectra showed peaks around 3-5 Hz and 6-10 Hz, corresponding to the movement frequencies. The coherence was statistically significant (P<0.05) in all subjects, with sources at the hand area of the primary motor cortex contralateral to the movement. CKC appears to be a promising and robust method for reliable and convenient functional mapping of the human motor cortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Brain Mapping / methods*
  • Data Interpretation, Statistical*
  • Evoked Potentials, Motor / physiology*
  • Humans
  • Magnetoencephalography / methods*
  • Motor Cortex / physiology*
  • Movement / physiology*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Volition / physiology*