Mesenchymal stem cells as an immunomodulatory therapeutic strategy for autoimmune diseases

Eyal Ben-Ami; Sonia Berrih-Aknin; Ariel Miller

doi:10.1016/j.autrev.2011.01.005

Mesenchymal stem cells as an immunomodulatory therapeutic strategy for autoimmune diseases

Autoimmun Rev. 2011 May;10(7):410-5. doi: 10.1016/j.autrev.2011.01.005. Epub 2011 Jan 20.

Authors

Eyal Ben-Ami¹, Sonia Berrih-Aknin, Ariel Miller

Affiliation

¹ Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. benami.eyal@gmail.com

PMID: 21256250
DOI: 10.1016/j.autrev.2011.01.005

Abstract

Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent progenitor cells which can be isolated from various human adult tissues. In recent years, MSCs have been shown to possess broad immunoregulatory capabilities, modulating both adaptive and innate immunity. This review discusses the documented immunomodulatory capabilities of the MSCs, the possible mechanisms underlying these functions and presents the potential of using this stem cell-based approach as an immunomodulatory tool for the treatment of autoimmune diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autoimmune Diseases / therapy*
Disease Models, Animal
Humans
Immunomodulation / immunology*
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells / immunology*
Transplantation, Autologous
Transplantation, Homologous
Treatment Outcome