Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update

Ann Emerg Med. 2011 May;57(5):449-61. doi: 10.1016/j.annemergmed.2010.11.030. Epub 2011 Jan 21.


We update an evidence-based clinical practice guideline for the administration of the dissociative agent ketamine for emergency department procedural sedation and analgesia. Substantial new research warrants revision of the widely disseminated 2004 guideline, particularly with respect to contraindications, age recommendations, potential neurotoxicity, and the role of coadministered anticholinergics and benzodiazepines. We critically discuss indications, contraindications, personnel requirements, monitoring, dosing, coadministered medications, recovery issues, and future research questions for ketamine dissociative sedation.

MeSH terms

  • Anesthetics, Dissociative* / administration & dosage
  • Anesthetics, Dissociative* / adverse effects
  • Conscious Sedation / methods
  • Conscious Sedation / standards*
  • Emergency Service, Hospital / standards*
  • Humans
  • Ketamine* / administration & dosage
  • Ketamine* / adverse effects
  • Practice Guidelines as Topic*


  • Anesthetics, Dissociative
  • Ketamine