Effects of zoledronic acid on healing of mandibular fractures: an experimental study in rabbits

J Oral Maxillofac Surg. 2011 Jun;69(6):1726-35. doi: 10.1016/j.joms.2010.07.063. Epub 2011 Jan 21.


Purpose: The purpose of the present study was to evaluate the effects of systemically administered zoledronic acid (ZA) on mandibular fracture healing in a rabbit model using radiodensitometric, biomechanical, histologic, and histomorphometric methods.

Materials and methods: A total of 36 skeletally mature male New Zealand white rabbits were used. The rabbits were randomly divided into 2 groups. A mandibular corpus fracture was created experimentally in all 36 rabbits. The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA, and the control group was administered only saline infusion during the procedure. All rabbits were sacrificed on the 21st postoperative day. Digital radiodensitometric analysis, a 3-point bending test, and histologic and histomorphometric examinations were performed on the harvested hemimandibles. The data were analyzed statistically.

Results: Biomechanical testing data showed that ZA treatment resulted in a significant increase in the healed bone strength. This result was supported by the radiologic, histologic, and histomorphometric findings.

Conclusions: The results of the present study have revealed that systemic administration of ZA accelerates and improves the bone healing of mandibular fractures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Bone Density Conservation Agents / pharmacology*
  • Diphosphonates / pharmacology*
  • Fracture Healing / drug effects*
  • Imidazoles / pharmacology*
  • Male
  • Mandibular Fractures / pathology
  • Mandibular Fractures / physiopathology*
  • Rabbits
  • Zoledronic Acid


  • Bone Density Conservation Agents
  • Diphosphonates
  • Imidazoles
  • Zoledronic Acid