Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 19 (3), 1167-71

Benzyl Benzoates: New Phlorizin Analogs as Mushroom Tyrosinase Inhibitors

Affiliations

Benzyl Benzoates: New Phlorizin Analogs as Mushroom Tyrosinase Inhibitors

Yuntai Fang et al. Bioorg Med Chem.

Abstract

In our research, 14 benzyl benzoates with hydroxyl(s) (3-16) were synthesized and their inhibitory activity on mushroom tyrosinase was tested. Results indicated that among these compounds, 4-hydroxybenzyl 3,5-dihydroxybenzoate (3), 4-hydroxybenzyl 2,4-dihydroxybenzoate (5), 4-hydroxybenzyl 2,4,6-dihydroxybenzoate (7), 3-hydroxybenzyl 3,5-dihydroxybenzoate (8), 3-hydroxybenzyl 2,4-dihydroxybenzoate (10) exhibited inhibitory activity with their IC(50) less than 10μM. Further studies showed these five compounds were competitive inhibitors of tyrosinase and their structure-activity relationships were investigated in this article.

Similar articles

See all similar articles

Publication types

MeSH terms

LinkOut - more resources

Feedback