Deposition of aerosols delivered by nasal route with jet and mesh nebulizers

Int J Pharm. 2011 Apr 4;407(1-2):87-94. doi: 10.1016/j.ijpharm.2011.01.024. Epub 2011 Jan 21.


Purpose: To quantify the amount of aerosol deposited in different parts of the airways with a commercially available nasal sonic jet nebulizer (NJN) using a sound effect, and to compare its performance with a new nasal mesh nebulizer (NMN).

Methods: Seven healthy non-smoking male volunteers aged 21-36 years with a mean weight of 77±10 kg were included in this single-center study. Both nebulizer systems were loaded with (99m)Tc-DTPA and scintigraphies were performed with a gamma camera. Particle size distribution of the aerosols produced by the two nebulizer systems was measured.

Results: There was no statistical difference between the two nebulizers in terms of fraction of particles smaller than 5 μm (44±4% vs 45±2%) (p>0.9). Aerosol deposition in the nasal region was 73±10% (% of aerosol deposited in airways) with the NJN, and 99±3% with the NMN (p=0.01). Total nasal deposition was 9.6±1.9% of the nebulizer charge with the NJN and 28.4±8.9% with the NMN (p=0.01). 0.5±0.3% of the nebulizer charge was deposited in the maxillary sinuses with the NJN, compared to 2.2±1.6% with the NMN (p=0.01).

Conclusion: Although the two nebulizers had the same particle size, NMN significantly improved aerosol deposition in nasal cavity and prevents deposition into the lungs.

Publication types

  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Administration, Intranasal
  • Adult
  • Aerosols
  • Gamma Cameras
  • Humans
  • Lung / metabolism
  • Male
  • Nebulizers and Vaporizers*
  • Particle Size
  • Radiopharmaceuticals / administration & dosage
  • Radiopharmaceuticals / pharmacokinetics*
  • Technetium Tc 99m Pentetate / administration & dosage
  • Technetium Tc 99m Pentetate / pharmacokinetics*
  • Tissue Distribution
  • Young Adult


  • Aerosols
  • Radiopharmaceuticals
  • Technetium Tc 99m Pentetate