Abstract
Rv1106c (hsd; 3β-hydroxysteroid dehydrogenase) is required by Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in infected macrophages or guinea pigs. We conclude that cholesterol is not required as a nutritional source during infection.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Bacterial Proteins / genetics
-
Cholesterol / metabolism*
-
Disease Models, Animal
-
Gene Deletion
-
Guinea Pigs
-
Macrophages / microbiology
-
Mycobacterium tuberculosis / metabolism*
-
Mycobacterium tuberculosis / pathogenicity*
-
Tuberculosis / microbiology*
-
Virulence
-
Virulence Factors / genetics
Substances
-
Bacterial Proteins
-
Virulence Factors
-
Cholesterol