The effect of pantothenic acid deficiency on keratinocyte proliferation and the synthesis of keratinocyte growth factor and collagen in fibroblasts

J Pharmacol Sci. 2011;115(2):230-4. doi: 10.1254/jphs.10224sc. Epub 2011 Jan 18.


It has been reported that pantothenic acid (vitamin B5) and panthenol, an alcohol derivative of pantothenic acid, have beneficial moisturizing effects on the skin. However, few studies have investigated the mechanism of action of pantothenic acid on skin tissues. We tried to clarify the role of pantothenic acid on skin function by using keratinocytes and fibroblasts. The depletion of pantothenic acid from the culture medium suppressed keratinocyte proliferation and promoted differentiation. Moreover, pantothenic acid depletion decreased the synthesis of keratinocyte growth factor and procollagen 4a2 in fibroblasts. These results suggest that pantothenic acid is essential for maintaining keratinocyte proliferation and differentiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Differentiation
  • Cell Proliferation*
  • Cells, Cultured
  • Collagen / biosynthesis*
  • Fibroblast Growth Factor 7 / biosynthesis*
  • Fibroblasts / metabolism*
  • Fibroblasts / physiology
  • Humans
  • Keratinocytes / cytology*
  • Keratinocytes / metabolism
  • Mice
  • Pantothenic Acid / deficiency*
  • Pantothenic Acid / physiology*


  • Fibroblast Growth Factor 7
  • Pantothenic Acid
  • Collagen