Fiber-optic and articulating arm implementations of laminar optical tomography for clinical applications

Biomed Opt Express. 2010 Sep 2;1(3):780-790. doi: 10.1364/BOE.1.000780.

Abstract

Laminar optical tomography (LOT) is a recently developed technique for depth-resolved in vivo imaging of absorption and fluorescence contrast. Until now, LOT has been implemented in a benchtop configuration, limiting accessibility to tissues and restricting imaging applications. Here we report on LOT implemented through an articulating arm and a fiber optic image bundle allowing flexible imaging for a range of clinical applications. We quantify the performance of these two implementations by imaging a tissue mimicking phantom.