Selection of silk-binding peptides by phage display

Biotechnol Lett. 2011 May;33(5):1069-73. doi: 10.1007/s10529-011-0519-6. Epub 2011 Jan 23.


Peptides that bind to silkworm-derived silk fibroin fiber were selected from a phage-displayed random peptide library. The selected silk-binding peptides contained a consensus sequence QSWS which is important for silk-binding as confirmed by binding assays using phage and synthetic peptides. With further optimization, we anticipate that the silk-binding peptides will be useful for functionalization of silk for biomaterial applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Motifs
  • Consensus Sequence
  • Fibroins / metabolism
  • Peptide Library*
  • Peptides / isolation & purification*
  • Peptides / metabolism*
  • Protein Binding
  • Silk / metabolism*


  • Peptide Library
  • Peptides
  • Silk
  • Fibroins