50-Gram glucose challenge test: is it indicative of outcomes in women without gestational diabetes mellitus?

J Matern Fetal Neonatal Med. 2011 Sep;24(9):1102-6. doi: 10.3109/14767058.2010.546450. Epub 2011 Jan 24.


Objective: To examine whether the 50-gram glucose challenge test (GCT) is associated with perinatal outcomes in women without gestational diabetes mellitus (GDM).

Methods: This is a retrospective cohort study of 13,789 women who received the GCT and did not have a diagnosis of GDM at the University of California, San Francisco UCSF. GCT values were categorized and examined as predictors of perinatal morbidity using chi-square test and multivariable logistic regression analyses adjusting for maternal characteristics.

Results: In women with an elevated GCT but without GDM, the odds of preeclampsia, cesarean delivery, and elevated birth weight were increased. The odds of large-for-gestational age status were increased with aOR 2.0 (95% CI 1.38-2.90) in the 160-179 mg/dl group. The odds of shoulder dystocia was increased with aOR 3.35 (CI 1.03-10.88) in the ≥180 mg/dl group.

Conclusion: In women without GDM, elevated 50-gram GCT values were associated with higher odds of perinatal morbidity. These findings further support evidence that impaired glucose tolerance is a continuum with possible associated adverse outcomes even at mild ranges; additional research is required to investigate appropriate interventions for women with abnormal screens for GDM.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • Diabetes, Gestational / diagnosis
  • Diabetes, Gestational / epidemiology
  • Dose-Response Relationship, Drug
  • Female
  • Glucose / administration & dosage*
  • Glucose Tolerance Test / methods
  • Humans
  • Hyperglycemia / blood
  • Hyperglycemia / epidemiology
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Complications / blood
  • Pregnancy Complications / epidemiology
  • Pregnancy Outcome* / epidemiology
  • Retrospective Studies
  • Young Adult


  • Glucose