Stressed and depressed? Check your GDNF for epigenetic repression

Courtney A Miller

doi:10.1016/j.neuron.2011.01.006

Stressed and depressed? Check your GDNF for epigenetic repression

Neuron. 2011 Jan 27;69(2):188-90. doi: 10.1016/j.neuron.2011.01.006.

Author

Courtney A Miller¹

Affiliation

¹ Department of Metabolism & Aging, Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33459, USA. cmiller@scripps.edu

Abstract

Some adults fail to adapt to chronic stress, developing symptoms of depression and anxiety. In this issue of Neuron, Uchida and colleagues link maladaptive stress responses to GDNF through a comprehensive investigation of the neurotrophic factor's regulation. Further, this study is an excellent example for investigators interested in neuroepigenetics research.

Publication types

Comment

Grants and funding

R00 DA024761/DA/NIDA NIH HHS/United States