Zero order spectrophotometric method for estimation of escitalopram oxalate in tablet formulations

J Young Pharm. 2010 Oct;2(4):420-3. doi: 10.4103/0975-1483.71626.


A new, simple, fast and reliable zero order spectrophotometric method has been developed for determination of Escitalopram Oxalate in bulk and tablet dosage forms. The quantitative determination of drug was carried out using the zero order values (absorbance) measured at 238 nm. Calibration graph constructed at 238 nm was linear in concentration range of 2-20 µg/ml with correlation coefficient 0.9999. The method was found to be precise, accurate, specific, and validated as per ICH guidelines and can be used for determination of Escitalopram Oxalate in tablet formulations.

Keywords: Escitalopram oxalate; validation; zero order spectrophotometry.