Cupric superoxo-mediated intermolecular C-H activation chemistry

J Am Chem Soc. 2011 Feb 16;133(6):1702-5. doi: 10.1021/ja110466q. Epub 2011 Jan 25.

Abstract

The new cupric superoxo complex [LCu(II)(O(2)(•-))](+), which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon / chemistry*
  • Copper / chemistry*
  • Hydrogen / chemistry*
  • Kinetics
  • Models, Molecular
  • Molecular Conformation
  • Organometallic Compounds / chemistry*
  • Oxidation-Reduction

Substances

  • Organometallic Compounds
  • Carbon
  • Copper
  • Hydrogen