Abstract
Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings and the clinical formulation of docetaxel, Taxotere.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Absorption
-
Antineoplastic Agents / administration & dosage
-
Antineoplastic Agents / chemistry
-
Crystallization / methods*
-
Diffusion
-
Docetaxel
-
Drug Compounding / methods
-
Lactic Acid / chemistry*
-
Nanocapsules / chemistry*
-
Nanocapsules / ultrastructure*
-
Particle Size
-
Polyglycolic Acid / chemistry*
-
Polylactic Acid-Polyglycolic Acid Copolymer
-
Taxoids / administration & dosage*
-
Taxoids / chemistry*
Substances
-
Antineoplastic Agents
-
Nanocapsules
-
Taxoids
-
Docetaxel
-
Polylactic Acid-Polyglycolic Acid Copolymer
-
Polyglycolic Acid
-
Lactic Acid