Relationship between interleukin-6 and cerebral deep white matter and periventricular hyperintensity in elderly women

Geriatr Gerontol Int. 2011 Jul;11(3):328-32. doi: 10.1111/j.1447-0594.2010.00686.x. Epub 2011 Jan 25.


Aim: We evaluated the relationships between serum levels of high-sensitivity C-reactive protein (hsCRP) and interleukin (IL)-6 with the severity of leukoaraiosis.

Methods: One hundred and thirty-seven elderly women who attended the Center for Comprehensive Care on Memory Disorders at Kyorin University Hospital were enrolled in this study. Leukoaraiosis was assessed by periventricular hyperintensity (PVH) score and deep white matter hyperintensity (DWMH) score.

Results: Serum log IL-6 level correlated with PVH and DWMH scores, but hsCRP did not. By multinomial logistic analysis, IL-6 was significantly related to DWMH score, independent of age and systolic blood pressure.

Conclusion: IL-6 is presumably an important marker of leukoaraiosis, as is the case with silent cerebral infarction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood
  • Brain / pathology*
  • C-Reactive Protein / analysis
  • Cerebral Infarction / diagnosis
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Leukoaraiosis / blood*
  • Leukoaraiosis / diagnosis
  • Magnetic Resonance Imaging*


  • Biomarkers
  • Interleukin-6
  • C-Reactive Protein