RADSeq: next-generation population genetics

Brief Funct Genomics. 2010 Dec;9(5-6):416-23. doi: 10.1093/bfgp/elq031.


Next-generation sequencing technologies are making a substantial impact on many areas of biology, including the analysis of genetic diversity in populations. However, genome-scale population genetic studies have been accessible only to well-funded model systems. Restriction-site associated DNA sequencing, a method that samples at reduced complexity across target genomes, promises to deliver high resolution population genomic data-thousands of sequenced markers across many individuals-for any organism at reasonable costs. It has found application in wild populations and non-traditional study species, and promises to become an important technology for ecological population genomics.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Genetic Variation
  • Genetics, Population*
  • Genome
  • Humans
  • Phylogeny
  • Polymorphism, Single Nucleotide
  • Restriction Mapping
  • Sequence Analysis, DNA / methods*