Synthetic associations are unlikely to account for many common disease genome-wide association signals

PLoS Biol. 2011 Jan 18;9(1):e1000580. doi: 10.1371/journal.pbio.1000580.


Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation
  • Crohn Disease / genetics
  • Genetic Linkage
  • Genetic Loci
  • Genetic Variation
  • Genetics, Population
  • Genome-Wide Association Study*
  • Humans
  • Models, Genetic*
  • Nod2 Signaling Adaptor Protein / genetics


  • NOD2 protein, human
  • Nod2 Signaling Adaptor Protein