[Nootropic and analgesic effects of Semax following different routes of administration]

Ross Fiziol Zh Im I M Sechenova. 2010 Oct;96(10):1014-23.
[Article in Russian]


Heptapeptide Semax (MEHFPGP) is the fragment of ACTH(4-10) analogue with prolonged neurotropic activity. The aim of the present work was to study the Semax effects on learning capability and pain sensitivity in white rats following intraperitoneal and intranasal administration in different doses. Semax nootropic effects were studied in the test of acquisition of passive avoidance task. Pain sensitivity was estimated in Randall-Selitto paw-withdrawal test. It was shown that Semax exerts nootropic and analgesic activities following intraperitoneal administration. Analysis of dependence of these effects on dose resulted in different dose-response curves. Following intranasal administration, Semax was more potent in learning improvement compared to intraperitoneal administration. The peptide failed to affect the animal pain sensitivity following intranasal administration as opposed to intraperitoneal administration. The data obtained suggest different mechanisms and brain structures involved in realization of the nootropic and analgesic effects of Semax.

Publication types

  • English Abstract

MeSH terms

  • Administration, Intranasal
  • Adrenocorticotropic Hormone / analogs & derivatives*
  • Adrenocorticotropic Hormone / pharmacology
  • Analgesics / pharmacology*
  • Animals
  • Injections, Intraperitoneal
  • Learning / drug effects*
  • Male
  • Nootropic Agents / pharmacology*
  • Pain / physiopathology*
  • Peptide Fragments / pharmacology*
  • Rats


  • Analgesics
  • Nootropic Agents
  • Peptide Fragments
  • ACTH (4-7), Pro-Gly-Pro-
  • Adrenocorticotropic Hormone