Genetic controls of Th17 cell differentiation and plasticity

Exp Mol Med. 2011 Jan 31;43(1):1-6. doi: 10.3858/emm.2011.43.1.007.


CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naïve T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2 cells, several novel effector T cell subsets have been recently identified, including Th17 cells. There has been rapid progress in characterizing the development and function of Th17 cells. Here I summarize and discuss on the genetic controls of their differentiation and emerging evidence on their plasticity. This information may benefit understanding and treating immune diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology*
  • Cell Differentiation
  • Cell Lineage
  • Cytokines / genetics*
  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Humans
  • Interleukin-17 / immunology
  • Interleukin-17 / metabolism
  • T-Lymphocytes, Regulatory
  • Th1 Cells / immunology
  • Th17 Cells / immunology*
  • Th2 Cells / immunology
  • Transcription Factors / genetics*
  • Transcription, Genetic


  • Cytokines
  • Interleukin-17
  • Transcription Factors