Modular MR-compatible lower leg exercise device for whole-body scanners

Skeletal Radiol. 2011 Oct;40(10):1349-54. doi: 10.1007/s00256-011-1098-2. Epub 2011 Jan 27.

Abstract

Purpose: To develop a modular MR-compatible lower leg exercise device for muscle testing using a clinical 3 T MR scanner.

Materials and methods: An exercise device to provide isotonic resistance to plantar- or dorsiflexion was constructed from nonferrous materials and designed for easy setup and use in a clinical environment. Validation tests were performed during dynamic MR acquisitions. For this purpose, the device was tested on the posterior lower leg musculature of five subjects during 3 min of exercise at 30% of maximum voluntary plantarflexion during 31-phosphorus MR spectroscopy ((31)P-MRS). Measures of muscle phosphocreatine (PCr), inorganic phosphate (Pi), and pH were obtained before, during, and after the exercise protocol.

Results: At the end of exercise regimen, muscle PCr showed a 28% decrease from resting levels (to 21.8 ± 3.9 from 30.4 ± 3.0 mM) and the average PCr recovery rate was 35.3 ± 8.3 s. Muscle Pi concentrations increased 123% (to 14.6 ± 4.7 from 6.5 ± 3.3 mM) and pH decreased 1.5% (to 7.06 ± 0.14 from 7.17 ± 0.07) from resting levels.

Conclusion: The described MR-compatible lower leg exercise was an effective tool for data acquisition during dynamic MR acquisitions of the calf muscles. The modular design allows for adaptation to other whole-body MR scanners and incorporation of custom-built mechanical or electronic interfaces and can be used for any MR protocol requiring dynamic evaluation of calf muscles.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Equipment Design
  • Exercise* / physiology
  • Humans
  • Lower Extremity / physiology*
  • Magnetic Resonance Imaging* / instrumentation
  • Male
  • Muscle, Skeletal / physiology*