Review
doi: 10.1016/S1701-2163(16)34772-7.
The fetal safety of benzodiazepines: an updated meta-analysis
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- PMID: 21272436
- DOI: 10.1016/S1701-2163(16)34772-7
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Review
The fetal safety of benzodiazepines: an updated meta-analysis
J Obstet Gynaecol Can.
2011 Jan.
Erratum in
- J Obstet Gynaecol Can. 2011 Apr;33(4):319
Abstract
Benzodiazepines are commonly used by women of reproductive age, and hence many pregnant women are exposed to them. An updated meta-analysis of their fetal safety synthesized nine studies with over one million pregnancies, yielding an odds ratio of 1.07 (95% CI 0.91 to 1.25). While benzodiazepines do not appear to increase teratogenic risk in general, case-controls suggest a twofold increased risk of oral cleft.
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