Associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA1c among adolescents in the United States

Diabetes Care. 2011 Mar;34(3):646-8. doi: 10.2337/dc10-1754. Epub 2011 Jan 27.

Abstract

Objective: Our objective was to examine the associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA(1c) in a nationally representative sample of adolescents in the U.S.

Research design and methods: We used data for 1,941 adolescents, aged 12-17 years, who participated in the National Health and Nutrition Examination Survey between 2001 and 2006.

Results: Adjusted concentrations of insulin were ~24% lower among male subjects with a concentration of vitamin D ≥ 75 nmol/L than among male subjects with a concentration of vitamin D <50 nmol/L (P = 0.003). Concentrations of vitamin D were inversely associated with concentrations of glucose only among Mexican American male subjects (P = 0.007). No significant associations between concentrations of vitamin D and HbA(1c) were detected.

Conclusions: Our results support an inverse association between concentrations of vitamin D and insulin primarily in adolescent male subjects.

MeSH terms

  • Adolescent
  • Blood Glucose / metabolism*
  • Child
  • Female
  • Glycated Hemoglobin A / metabolism*
  • Humans
  • Insulin / blood*
  • Male
  • United States
  • Vitamin D / blood*

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • Insulin
  • Vitamin D