Biological and clinical aspects of interleukin 6

Immunol Today. 1990 Dec;11(12):443-9. doi: 10.1016/0167-5699(90)90173-7.


Interleukin 6 (IL-6) is a multi-functional cytokine that is produced by a range of cells and plays a central role in host defense mechanisms. Abnormal production of IL-6 has been suggested to be involved in glomerulonephritis, plasmacytomagenesis and in the pathogenesis of autoimmune diseases. In this review, Toshio Hirano and colleagues discuss the possible involvement of IL-6 in a variety of diseases, the regulatory mechanism(s) of expression of the IL-6 gene and the structure and function of the IL-6 receptor.

Publication types

  • Review

MeSH terms

  • Acute-Phase Reaction
  • Animals
  • Autoimmune Diseases / etiology
  • Gene Expression Regulation
  • Glomerulonephritis / etiology
  • Humans
  • Interleukin-6 / genetics
  • Interleukin-6 / physiology*
  • Mice
  • Mice, Transgenic
  • Multiple Myeloma / etiology
  • Receptors, Immunologic / analysis
  • Receptors, Interleukin-6


  • Interleukin-6
  • Receptors, Immunologic
  • Receptors, Interleukin-6