A database for the analysis of immunity genes in Drosophila: PADMA database

Fly (Austin). Apr-Jun 2011;5(2):155-61. doi: 10.4161/fly.5.2.14674. Epub 2011 Apr 1.

Abstract

While microarray experiments generate voluminous data, discerning trends that support an existing or alternative paradigm is challenging. To synergize hypothesis building and testing, we designed the Pathogen Associated Drosophila MicroArray (PADMA) database for easy retrieval and comparison of microarray results from immunity-related experiments (www.padmadatabase.org). PADMA also allows biologists to upload their microarray-results and compare it with datasets housed within PADMA. We tested PADMA using a preliminary dataset from Ganaspis xanthopoda-infected fly larvae, and uncovered unexpected trends in gene expression, reshaping our hypothesis. Thus, the PADMA database will be a useful resource to fly researchers to evaluate, revise, and refine hypotheses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Computational Biology
  • Databases, Genetic*
  • Drosophila / genetics*
  • Drosophila Proteins / genetics*
  • Immunity, Innate / genetics
  • Oligonucleotide Array Sequence Analysis

Substances

  • Drosophila Proteins