[Estimate of the dosage for radioiodine ablation of the thyroid gland in male Wistar rats]

Zentralbl Veterinarmed A. 1990 Dec;37(10):747-51.
[Article in German]

Abstract

The aim of this investigation was to determine the radioiodine dose necessary for the ablation of the thyroid gland in male Wistar rats. By a mathematical extrapolation of the kinetics of iodine-131, the radioisotope dose in the thyroid was calculated to be 467971 or 401540 rad after an intraperitoneal administration of 1 x 0.8 mCi (29.6 MBq) or 1 x 1.0 mCi (37.0 MBq) iodine-131, respectively. Because lower radioiodine activities did not result in a complete destruction of the thyroid (controlled by scintigraphic methods), it can be concluded that about 400,000 rad are necessary for the complete ablation of the thyroid gland by radioiodine.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Injections, Intraperitoneal
  • Iodine Radioisotopes / administration & dosage*
  • Iodine Radioisotopes / pharmacokinetics
  • Male
  • Rats
  • Rats, Inbred Strains
  • Thyroid Gland / radiation effects*

Substances

  • Iodine Radioisotopes