Fractionated CO2 laser skin rejuvenation

Dermatol Ther. Jan-Feb 2011;24(1):41-53. doi: 10.1111/j.1529-8019.2010.01377.x.


Fractional photothermolysis has been reported in the literature to improve both the pigmentary and textural changes associated with photoaging. The objective of the study was to review the literature of non-ablative fractional laser (NAFL) and ablative fractional laser (AFL) resurfacing for the treatment of photoaging. This is a review of the Medline literature evaluating NAFL and AFL for photoaging. Review of the literature supports the use of NAFL and AFL as safe and effective treatments for photoaging. It is likely that the controlled, limited dermal heating of fractional resurfacing initiates a cascade of events in which normalization of the collagenesis/collagenolysis cycle occurs. The advent of fractionated resurfacing for the treatment of photoaging is a significant advance over ablative laser resurfacing treatments, which were complicated by prolonged erythema, delayed onset hypopigmentation, and scarring.

Publication types

  • Review

MeSH terms

  • Cosmetic Techniques
  • Dose Fractionation, Radiation
  • Female
  • Humans
  • Hypopigmentation / etiology
  • Laser Therapy / adverse effects
  • Laser Therapy / instrumentation
  • Laser Therapy / methods*
  • Lasers, Gas / therapeutic use
  • Male
  • Rejuvenation*
  • Skin Aging*
  • Treatment Outcome