Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Aβ aggregation in SH-SY5Y cells

Neurosci Lett. 2011 Apr 1;492(2):76-9. doi: 10.1016/j.neulet.2011.01.055. Epub 2011 Jan 27.


Alzheimer's disease (AD) is a common form of neurodegenerative disease. Mounting evidence suggests that metal ions play a key role in the aggregation of amyloid β peptide (Aβ), which acts as a factor or cofactor in the etiopathogenesis of AD. Therefore, inhibition of Aβ aggregation emerges as a potential approach for the treatment of AD. We have found that baicalin can interact with copper directly and inhibits Aβ1-42 aggregation. In addition, baicalin protects SH-SY5Y cells from oxidative injuries induced by Aβ1-42 aggregation through decreasing H(2)O(2) production that is normally formed as a deleterious by-product of beta amyloid aggregation and the formation of plaques. Taken together, these data indicate that baicalin may be a potential agent to inhibit Aβ aggregation and thereby delay, mitigate or modify the progression of neurodegenerative diseases such as AD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Peptides / pharmacology
  • Amyloid beta-Peptides / ultrastructure
  • Antioxidants / pharmacology*
  • Cell Line, Tumor
  • Copper / metabolism
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Flavanones / pharmacology*
  • Humans
  • Hydrogen Peroxide / metabolism*
  • Neuroblastoma / pathology
  • Oxidative Stress / drug effects*
  • Peptide Fragments / metabolism*
  • Peptide Fragments / pharmacology
  • Peptide Fragments / ultrastructure
  • Phenol / pharmacology
  • Plant Extracts / pharmacology
  • Scutellaria baicalensis
  • Time Factors


  • Amyloid beta-Peptides
  • Antioxidants
  • Flavanones
  • Peptide Fragments
  • Plant Extracts
  • Scutellaria baicalensis extract
  • amyloid beta-protein (1-42)
  • Phenol
  • baicalein
  • Copper
  • Hydrogen Peroxide