The contribution of animal models to the understanding of the host range and virulence of influenza A viruses

Microbes Infect. 2011 May;13(5):502-15. doi: 10.1016/j.micinf.2011.01.014. Epub 2011 Jan 27.

Abstract

Since ferrets were first used in 1933 during the initial isolation of influenza A viruses, animal models have been critical for influenza research. The following review discusses the contribution of mice, ferrets, and non-human primates to the study of influenza virus host range and pathogenicity.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Ferrets / virology
  • Host Specificity*
  • Humans
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / pathogenicity
  • Influenza A virus / classification
  • Influenza A virus / genetics
  • Influenza A virus / pathogenicity*
  • Influenza, Human / physiopathology*
  • Influenza, Human / virology
  • Mice / virology
  • Orthomyxoviridae Infections / physiopathology
  • Orthomyxoviridae Infections / virology
  • Primates / virology
  • Virulence