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. 2011 May 1;69(9):883-9.
doi: 10.1016/j.biopsych.2010.12.011. Epub 2011 Jan 28.

Mapping Repetition Suppression of the N100 Evoked Response to the Human Cerebral Cortex

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Free PMC article

Mapping Repetition Suppression of the N100 Evoked Response to the Human Cerebral Cortex

Nash N Boutros et al. Biol Psychiatry. .
Free PMC article

Abstract

Background: Repetition suppression (RS) phenomena, such as those observed using paired-identical-stimulus (S1-S2) paradigms, likely reflect adaptive functions such as habituation and, more specifically, sensory gating.

Methods: To better characterize the neural networks underlying RS, we analyzed auditory S1-S2 data from electrodes placed on the cortices of 64 epilepsy patients who were being evaluated for surgical therapy. We identified regions with maximal amplitude responses to S1 (i.e., stimulus registration regions), regions with maximal suppression of responses to S2 relative to S1 (i.e., RS), and regions with no or minimal RS.

Results: Auditory perceptual regions, such as the superior temporal gyri, were shown to have significant initial registration activity (i.e., strong response to S1). Several prefrontal, cingulate, and parietal lobe regions were found to exhibit stronger RS than those recorded from the auditory perceptual areas.

Conclusions: The data strongly suggest that the neural network underlying repetition suppression may include regions not previously thought to be involved, such as the parietal and cingulate cortexes. In addition, the data also support the notion that the initial response to stimuli and the ability to suppress the stimuli if repeated are two separate, but likely related, functions.

Figures

Figure 1
Figure 1
The ten cortical regions exhibiting maximal gating of the N100 (dark shaded regions), the ten regions exhibiting the least gating (light shaded areas), and the evoked responses (S1-thick line and S2-thin line) from each region.
Figure 2
Figure 2
Topographies of the cortical potentials and estimated current densities for three selected subjects (out of 20) showing differences in cortical potential distributions and generators of S1 signal N100 potential (stimulus registration) and S1–S2 difference waves (sensory gating). Differences are mostly shown in terms of individual regions that are involved in both (subject 16) or predominantly in one (subjects 3 and 18) of two processes; stimulus registration and repetition suppression. Data from 20 subjects are shown in the Suplemental Materials section.

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