Genetic diversity of 17 Y-short tandem repeats in Indian population

Tania Ghosh; D Kalpana; Sanjukta Mukerjee; Meeta Mukherjee; Anil Kumar Sharma; Subhankar Nath; Varsha Rajesh Rathod; Mukesh Kumar Thakar; Ganga Nath Jha

doi:10.1016/j.fsigen.2010.12.007

Genetic diversity of 17 Y-short tandem repeats in Indian population

Forensic Sci Int Genet. 2011 Aug;5(4):363-7. doi: 10.1016/j.fsigen.2010.12.007. Epub 2011 Jan 28.

Authors

Tania Ghosh¹, D Kalpana, Sanjukta Mukerjee, Meeta Mukherjee, Anil Kumar Sharma, Subhankar Nath, Varsha Rajesh Rathod, Mukesh Kumar Thakar, Ganga Nath Jha

Affiliation

¹ Central Forensic Science Laboratory, Directorate of Forensic Science Services, Ministry of Home Affairs, Govt. of India, 30 Gorachand Road, Park Circus, Kolkata 700014, West Bengal, India.

PMID: 21277272
DOI: 10.1016/j.fsigen.2010.12.007

Abstract

Seventeen short tandem repeats (DYS389I, DYS390, DYS389II, DYS19, DYS385a/b, DYS393, DYS391, DYS392, DYS439, DYS438, DYS456, DYS458, DYS635, Y(GATA)H4, DYS437, and DYS448) from the non-recombining region of the human Y-chromosome were analyzed in 750 unrelated males representing four major linguistic families of India using AmpFlSTR(®) Yfiler(®) PCR Amplification kit. A total of 612 distinct haplotypes were observed, of which 545 were unique. Rare alleles for the loci DYS456, DYS458, DYS635, Y(GATA)H4, and duplication at the loci DYS389I and DYS389II were also observed. To understand the genetic diversity of the Indian population, and utility of Y-STRs in forensics, the locus diversity, haplotype diversity, and discrimination capacity in all populations was determined. MDS plot based on pairwise Φ(st) and AMOVA revealed the high genetic heterogeneity among the Indian populations due to linguistic diversity and social stratification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Y*
DNA Fingerprinting
Ethnicity / genetics*
Genetic Variation
Genetics, Population*
Haplotypes
Humans
India
Male
Microsatellite Repeats*
Polymerase Chain Reaction