Dietary Aloin, Aloesin, or Aloe-Gel Exerts Anti-Inflammatory Activity in a Rat Colitis Model

Life Sci. 2011 Mar 14;88(11-12):486-92. doi: 10.1016/j.lfs.2011.01.010. Epub 2011 Jan 26.

Abstract

Aims: Aloe has been a very popular folk remedy for inflammation-related pathological conditions despite the lack of studies reporting its efficacy in vivo. The present study evaluated the anti-inflammatory effects of aloe components (aloin, aloesin and aloe-gel) known to be biologically active in the rat model of colitis.

Main methods: Male Sprague Dawley rats were fed experimental diets for 2 weeks before and during the induction of colitis. Drinking water containing 3% dextran sulfate sodium (DSS) was provided for 1 week to induce colitis. At the end of the experimental period, clinical and biochemical markers were compared.

Key findings: Plasma leukotriene B(4) (LTB(4)) and tumor necrosis factor-α (TNF-α) concentrations were significantly decreased in all groups supplemented with aloe components compared to the colitis control group (p<0.05). Animals fed both a 0.1% and 0.5% aloesin supplemented diet showed colonic myeloperoxidase (MPO) activities which were decreased by 32.2% and 40.1%, respectively (p<0.05). Colonic mucosa TNF-α and interleukin-1ß (IL-1β) mRNA expressions were significantly reduced in all animals fed aloin, aloesin, or aloe-gel (p<0.05).

Significance: Dietary supplementation of aloe components ameliorates intestinal inflammatory responses in a DSS-induced ulcerative colitis rat model. In particular, aloesin was the most potent inhibitor. Further studies are required for a more complete understanding of the specific mechanism of the action of these supplements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aloe / chemistry*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Chromones / administration & dosage
  • Chromones / therapeutic use*
  • Colitis / drug therapy*
  • Colitis / immunology
  • Colitis / pathology
  • Colon / drug effects
  • Colon / enzymology
  • Colon / immunology
  • Colon / pathology
  • Diet
  • Dietary Supplements*
  • Disease Models, Animal
  • Emodin / administration & dosage
  • Emodin / analogs & derivatives*
  • Emodin / therapeutic use
  • Gels
  • Glucosides / administration & dosage
  • Glucosides / therapeutic use*
  • Interleukin-1beta / immunology
  • Leukotriene B4 / blood
  • Male
  • Peroxidase / metabolism
  • Plant Preparations / administration & dosage
  • Plant Preparations / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Chromones
  • Gels
  • Glucosides
  • Interleukin-1beta
  • Plant Preparations
  • Tumor Necrosis Factor-alpha
  • Leukotriene B4
  • Peroxidase
  • Emodin
  • alloin
  • aloesin