Common Variants in ZNF365 Are Associated With Both Mammographic Density and Breast Cancer Risk

Nat Genet. 2011 Mar;43(3):185-7. doi: 10.1038/ng.760. Epub 2011 Jan 30.

Abstract

High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Breast / anatomy & histology*
  • Breast Neoplasms / genetics*
  • DNA-Binding Proteins / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Genetic Variation*
  • Genome-Wide Association Study
  • Humans
  • Mammography
  • Middle Aged
  • Risk
  • Transcription Factors / genetics*

Substances

  • DNA-Binding Proteins
  • Transcription Factors
  • ZNF365 protein, human