Raging hormones: gender and renal disease

Kidney Int. 2011 Feb;79(4):382-4. doi: 10.1038/ki.2010.474.

Abstract

Gender affects the progression of renal disease. In a variety of animal models and in certain human renal diseases, females exhibit a more modest course of kidney disease. Estrogens and testosterone have been implicated in this gender disparity. Doublier and colleagues explore the direct effects of sex hormones on podocyte viability in the α-estrogen receptor knockout (αERKO) mouse. They report that testosterone induces, and estradiol inhibits, podocyte damage in this model.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • Disease Models, Animal
  • Estradiol / pharmacology
  • Estrogen Receptor alpha / deficiency
  • Estrogen Receptor alpha / genetics
  • Female
  • Gonadal Steroid Hormones / physiology*
  • Humans
  • Kidney Diseases / etiology*
  • Kidney Diseases / pathology
  • Kidney Diseases / physiopathology*
  • Male
  • Mice
  • Mice, Knockout
  • Podocytes / drug effects
  • Podocytes / pathology
  • Sex Characteristics
  • Testosterone / pharmacology

Substances

  • Estrogen Receptor alpha
  • Gonadal Steroid Hormones
  • Testosterone
  • Estradiol