[Association between vitamin D deficiency and metabolic syndrome]

Rev Med Chil. 2010 Oct;138(10):1312-8. Epub 2011 Jan 10.
[Article in Spanish]


Vitamin D has an essential role in calcium metabolism and bone health. Vitamin D3 or cholecalciferol is synthesized from 7-dehydrocholesterol or provitamin D3, by sunlight ultraviolet radiation to the skin. 7-dehydrocholesterol is subsequently hydroxylated in the liver and then in the kidney to produce 1,25-(OH)2D3, the active metabolite that binds to specific receptors (VDR) in target tissues, mainly bone and intestine. Other tissues, such as the immune and cardiovascular system, have also VDR. Vitamin D deficiency can induce rickets in children and osteomalacia and osteoporosis in adults. A possible inverse association between vitamin D levels and the prevalence of metabolic syndrome has been proposed. Vitamin D deficiency increases the risk of type 1 diabetes, insulin resistance, and hypertension, key components of this syndrome. However, other studies have not confirmed this association. Further clinical and experimental studies are needed to ascertain the role of vitamin D in metabolic syndrome.

Publication types

  • Review

MeSH terms

  • Humans
  • Metabolic Syndrome / etiology*
  • Risk Factors
  • Vitamin D / metabolism
  • Vitamin D Deficiency / complications*


  • Vitamin D