An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents

Arthritis Rheum. 2011 Feb;63(2):337-45. doi: 10.1002/art.30114.

Abstract

Objective: To assess the efficacy and safety of R788 (fostamatinib disodium), an inhibitor of spleen tyrosine kinase (Syk), in patients with active rheumatoid arthritis (RA) that did not respond to biologic therapies.

Methods: A total of 219 patients with active RA in whom treatment with biologic agents had failed were enrolled in a 3-month multicenter, randomized, double-blind, placebo-controlled trial of R788. The primary end point was the percentage of patients who met the American College of Rheumatology 20% improvement criteria (achieved an ACR20 response) at month 3. Secondary end points included changes in inflammation and damage, as assessed by magnetic resonance imaging (MRI), and changes in the Disease Activity Score.

Results: The ACR20 response in the R788 100 mg twice daily group was 38%, versus 37% in the placebo group, at month 3. No significant differences were achieved in the ACR20, ACR50, or ACR70 response levels at 3 months. There were differences between the groups from baseline to month 3 in the secondary end points C-reactive protein (CRP) level and synovitis score on MRI. There were baseline differences in steroid use, prior biologic use, and synovitis score on MRI between the R788 group and the placebo group that may have affected the outcomes. A high placebo response rate was seen in this trial, and exploratory analysis suggested that this may in part have been driven by patients who entered the trial with an elevated erythrocyte sedimentation rate but normal CRP level.

Conclusion: Our findings indicate that there were no differences in the primary end point between the R788 and placebo groups. Differences were observed between the R788 and placebo groups in secondary end points, particularly in those patients who entered the study with an elevated CRP level.

Trial registration: ClinicalTrials.gov NCT00665926.

Publication types

  • Clinical Trial, Phase II
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antirheumatic Agents / therapeutic use*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / enzymology
  • Arthritis, Rheumatoid / physiopathology
  • Dose-Response Relationship, Drug
  • Drug Resistance
  • Enzyme Inhibitors / therapeutic use*
  • Female
  • Health Status
  • Humans
  • Immunologic Factors / pharmacology
  • Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
  • Joints / drug effects
  • Joints / physiopathology
  • Male
  • Middle Aged
  • Oxazines / therapeutic use*
  • Prodrugs / therapeutic use*
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Pyridines / therapeutic use*
  • Severity of Illness Index
  • Syk Kinase
  • Treatment Outcome
  • Young Adult

Substances

  • Antirheumatic Agents
  • Enzyme Inhibitors
  • Immunologic Factors
  • Intracellular Signaling Peptides and Proteins
  • Oxazines
  • Prodrugs
  • Pyridines
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase
  • fostamatinib

Associated data

  • ClinicalTrials.gov/NCT00665926