Comparison of diagnostic accuracy of saline infusion sonohysterography, transvaginal sonography and hysteroscopy

J Obstet Gynaecol. 2011;31(1):54-8. doi: 10.3109/01443615.2010.532246.

Abstract

We aimed to compare the accuracy of transvaginal sonography (TVS), saline infusion sonohysterography (SIS) and hysteroscopy (HS) for uterine pathologies among infertile women. A total of 346 patients were selected for operative hysteroscopy, following SIS after TVS. SİS was performed with a Cook Soft 500 IVF catheter. Sensitivity, specificity, positive and negative predictive values (PPV, NPV) were calculated to compare the accuracy of TVS, SIS and hysteroscopy for uterine abnormalities. SIS showed a sensitivity of 87%, specificity of 100% and PPV of 100% for endometrial hyperplasia, and a sensitivity and NPV of 100% for polypoid lesions. For submucosal myoma SIS showed a sensitivity of 99% with PPV of 96%. Hysteroscopy had a sensitivity, specificity, PPV and NPV of 98%, 83%, 96% and 91%, respectively for overall uterine pathologies. Finally, SIS seems to be superior to TVS, for uterine pathologies, with respect to hysteroscopy as the gold standard.

Publication types

  • Clinical Trial
  • Comparative Study
  • Validation Study

MeSH terms

  • Adult
  • Biopsy
  • Female
  • Humans
  • Hysteroscopy / methods
  • Hysteroscopy / standards*
  • Infertility, Female / diagnostic imaging*
  • Infertility, Female / pathology*
  • Leiomyoma / diagnostic imaging
  • Leiomyoma / pathology
  • Menorrhagia / diagnostic imaging
  • Menorrhagia / pathology
  • Polyps / diagnostic imaging
  • Polyps / pathology
  • Predictive Value of Tests
  • Pregnancy
  • Reference Standards
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sodium Chloride
  • Ultrasonography / methods
  • Ultrasonography / standards*
  • Uterine Diseases / diagnostic imaging
  • Uterine Diseases / pathology
  • Uterine Neoplasms / diagnostic imaging
  • Uterine Neoplasms / pathology
  • Vagina

Substances

  • Sodium Chloride