Inactivity of terbinafine in a rat model of pulmonary aspergillosis

Eur J Clin Microbiol Infect Dis. 1990 Nov;9(11):832-5. doi: 10.1007/BF01967386.

Abstract

In a model of bronchopulmonary aspergillosis terbinafine did not improve survival of experimental animals in doses up to 80 mg/kg/day despite adequate lung concentrations. Pretreatment and aerosolization of the compound were also ineffective. Terbinafine was markedly less active in vitro when serum was used instead of Yeast-Nitrogen-Glucose-broth. It is concluded that a lack of bioavailability in the presence of serum may explain the lack of activity of terbinafine in experimental aspergillosis.

MeSH terms

  • Aerosols
  • Amphotericin B / therapeutic use
  • Animals
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / pharmacokinetics
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / drug therapy*
  • Aspergillus flavus / drug effects
  • Aspergillus fumigatus / drug effects
  • Aspergillus niger / drug effects
  • Biological Availability
  • Disease Models, Animal
  • Lung / metabolism
  • Lung Diseases, Fungal / drug therapy*
  • Male
  • Naphthalenes / administration & dosage
  • Naphthalenes / pharmacokinetics
  • Naphthalenes / therapeutic use*
  • Rats
  • Rats, Inbred Strains
  • Terbinafine

Substances

  • Aerosols
  • Antifungal Agents
  • Naphthalenes
  • Amphotericin B
  • Terbinafine