Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans

PLoS One. 2011 Jan 21;6(1):e16317. doi: 10.1371/journal.pone.0016317.

Abstract

An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • African Americans / genetics*
  • Alleles
  • Crohn Disease / genetics
  • European Continental Ancestry Group / genetics
  • GTP-Binding Proteins / genetics*
  • GTP-Binding Proteins / physiology
  • Genetic Markers
  • Genetic Predisposition to Disease / ethnology*
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Polymorphism, Single Nucleotide*
  • Tuberculosis / ethnology*
  • Tuberculosis / genetics*

Substances

  • Genetic Markers
  • GTP-Binding Proteins
  • IRGM protein, human