Hybrid bidentate phosphorus ligands in asymmetric catalysis: privileged ligand approach vs. combinatorial strategies

Org Biomol Chem. 2011 Mar 21;9(6):1704-13. doi: 10.1039/c0ob00732c. Epub 2011 Jan 31.


In this perspective the development of chiral phosphorus ligands for asymmetric catalysis is discussed, with a special focus on hybrid bidentate phosphorus ligands, in particular phosphine-phosphoramidites. An attempt is made to compare privileged ligand and combinatorial approaches to ligand development--for which the class of phosphine-phosphoramidite ligands is well suited--highlighting differences, similarities and their complementary use.

MeSH terms

  • Catalysis
  • Combinatorial Chemistry Techniques
  • Hydrogenation
  • Ligands
  • Molecular Structure
  • Nitrogen / chemistry
  • Phosphorus / chemistry*
  • Stereoisomerism


  • Ligands
  • Phosphorus
  • Nitrogen