Age-related changes of the oligodendrocytes in rat subcortical white matter

Anat Rec (Hoboken). 2011 Mar;294(3):487-93. doi: 10.1002/ar.21332. Epub 2011 Jan 31.


The age-related changes, of the oligodendrocytes in rat subcortical white matter, were investigated in this study. The oligodendrocytes in subcortical white matter were labeled with anti-2',3'-cyclic nucleotide 3'-phosphodiesterase antibody (anti-CNPase antibody, a specific marker of oligodendrocytes). The total number of CNPase(+) cells was estimated with an unbiased stereological technique, the optical fractionator. In this study, we found that the total number of CNPase(+) cells in the young male rats and aged male rats was 14.4 ± 1.2 × 10(6) and 9.0 ± 1.0 × 10(6) , respectively. The total number of the CNPase(+) cells in the subcortical white matter of aged rats was significantly decreased by 37.5% when compared to young male rats. This study demonstrated that there was an aged-related decrease of the oligodendrocytes in subcortical white matter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',3'-Cyclic-Nucleotide Phosphodiesterases / metabolism
  • Aging / physiology*
  • Animals
  • Cerebral Cortex / cytology*
  • Cerebral Cortex / immunology
  • Cerebral Cortex / metabolism*
  • Immunoenzyme Techniques
  • Male
  • Nerve Fibers, Myelinated / immunology
  • Nerve Fibers, Myelinated / metabolism*
  • Oligodendroglia / metabolism*
  • Rats
  • Rats, Wistar


  • 2',3'-Cyclic-Nucleotide Phosphodiesterases