Background aims: Recalcitrant diabetic wounds are not responsive to the most common treatments. Bone marrow-derived stem cell transplantation is used for the healing of chronic lower extremity wounds.
Methods: We report on the treatment of eight patients with aggressive, refractory diabetic wounds. The marrow-derived cells were injected/applied topically into the wound along with platelets, fibrin glue and bone marrow-impregnated collagen matrix.
Results: Four weeks after treatment, the wound was completely closed in three patients and significantly reduced in the remaining five patients.
Conclusions: Our study suggests that the combination of the components mentioned can be used safely in order to synergize the effect of chronic wound healing.