Tolytoxin and new scytophycins from three species of Scytonema

J Nat Prod. 1990 Nov-Dec;53(6):1533-42. doi: 10.1021/np50072a021.

Abstract

Tolytoxin [1], the major cytotoxin associated with Scytonema mirabile strain BY-8-1, Scytonema burmanicum strain DO-4-1 and Scytonema ocellatum strains DD-8-1, FF-65-1, and FF-66-3, has been shown to be 6-hydroxy-7-O-methylscytophycin B. Minor amounts of three other new cytotoxic scytophycins, 6-hydroxyscytophycin B [2], 19-O-demethylscytophycin C [3], and 6-hydroxy-7-O-methylscytophycin E [4], have also been isolated from these cyanophytes. The gross structures and stereochemistry are based on nmr and cd analysis and on comparison with scytophycins A-E.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antifungal Agents / isolation & purification*
  • Antineoplastic Agents / isolation & purification*
  • Cyanobacteria / analysis*
  • Drug Screening Assays, Antitumor
  • Fungi / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Pyrans / chemistry
  • Pyrans / isolation & purification*
  • Pyrans / pharmacology
  • Tumor Cells, Cultured

Substances

  • 6-hydroxy-7-O-methylscytophycin E
  • Antifungal Agents
  • Antineoplastic Agents
  • Pyrans
  • tolytoxin
  • 6-hydroxyscytophycin B
  • 19-O-demethylscytophycin C