Abstract
Tolytoxin [1], the major cytotoxin associated with Scytonema mirabile strain BY-8-1, Scytonema burmanicum strain DO-4-1 and Scytonema ocellatum strains DD-8-1, FF-65-1, and FF-66-3, has been shown to be 6-hydroxy-7-O-methylscytophycin B. Minor amounts of three other new cytotoxic scytophycins, 6-hydroxyscytophycin B [2], 19-O-demethylscytophycin C [3], and 6-hydroxy-7-O-methylscytophycin E [4], have also been isolated from these cyanophytes. The gross structures and stereochemistry are based on nmr and cd analysis and on comparison with scytophycins A-E.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antifungal Agents / isolation & purification*
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Antineoplastic Agents / isolation & purification*
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Cyanobacteria / analysis*
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Drug Screening Assays, Antitumor
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Fungi / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Pyrans / chemistry
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Pyrans / isolation & purification*
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Pyrans / pharmacology
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Tumor Cells, Cultured
Substances
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6-hydroxy-7-O-methylscytophycin E
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Antifungal Agents
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Antineoplastic Agents
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Pyrans
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tolytoxin
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6-hydroxyscytophycin B
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19-O-demethylscytophycin C