Catalytic asymmetric syntheses of isoxazoline-N-oxides under phase-transfer conditions

Taichi Kano; Akihiro Yamamoto; Sunhwa Song; Keiji Maruoka

doi:10.1039/c0cc05786j

Catalytic asymmetric syntheses of isoxazoline-N-oxides under phase-transfer conditions

Chem Commun (Camb). 2011 Apr 21;47(15):4358-60. doi: 10.1039/c0cc05786j. Epub 2011 Feb 1.

Authors

Taichi Kano¹, Akihiro Yamamoto, Sunhwa Song, Keiji Maruoka

Affiliation

¹ Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.

PMID: 21286641
DOI: 10.1039/c0cc05786j

Abstract

Catalytic asymmetric syntheses of various isoxazoline-N-oxides have been accomplished by asymmetric phase-transfer conjugate addition of bromomalonate to nitroolefins and subsequent ring-closing O-alkylation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Isoxazoles / chemical synthesis*
Isoxazoles / chemistry*
Stereoisomerism

Substances

Isoxazoles